Invited experts

The following experts have been invited to share their experience and discuss the clinical cases

  • Dr Tadej Avcin is a pediatric rheumatologist from Ljubljana in Slovenia. He speakes about the clinical aspects of antiphospholipid antibodies.

  • Dr Kathleen O'Neil is a young retired pediatric rheumatologist from Indianapolis in the USA. She focuses on the analysis of the laboratory tests.

Course curriculum

  • 2

    Pediatric Antiphospholipid Syndrome - Tadej Avcin

    • Introduction

    • Pathogenic mecanism of antiphospholipid antibodies (aPL)

      FREE PREVIEW
    • Classification criteria

    • Clinical manifestations not yet considered as classification criteria

    • Management

    • Question: What is the value of IgA, anticardiolipin and Beta2GP1

    • Question: APLA syndrome but with a negative result for APLA?

    • Question: Why do you think the risk ratio for IgG is higher than that for IgM?

    • Question: What is risk of thrombosis in patients with infection-induced APLA?

    • Question: In patients with thrombocytopenia as a non-thrombotic manifestation of APLA, in which platelet count do you think the use of aspirin would be safe?

    • Question: Is it mandatory to put SLE patients associated with APS on profilaxis treatment even if there is no tromboembolic event?

    • Question: Delay of 12 weeks between 2 APLA tests

    • Questions answered by text: Use of Rivaroxaban?

    • Comments from Kathleen O'Neil

  • 3

    How to interpret laboratory results - Kathleen O'Neil

    • Introduction

    • Introduction clinical case "Kimmy"

    • Classification of APS

      FREE PREVIEW
    • Indication for APS testing

    • What lab studies for suspected APS?

    • Lupus Anti-coagulant (LAC)

    • Anti-Cardiolipin Antibodies (ELISA)

    • Anti-B2 glycoprotein I Antibody Assay

    • Which test is meaningful and how to interpret

    • What did we do for "Kimmy"

    • Question: What do you think about primary APS that over time evolve into Lupus?

    • References for APS testing

    • Question: which test prioritize in a ressource challenged setting?

  • 4

    APLA clinical cases

    • Cutaneous manifestation of APS

      FREE PREVIEW
    • Cutaneous manifestation of APS: comments from Kathleen O'Neil and Tadej Avcin

    • Case with APS and pyoderma gangrenosum

    • Hematological manifestations of APS

    • Hematological manifestations of APS: comments from Kathleen O'Neil and Tadej Avcin

    • How to go forward with this case?

  • 5

    Quiz of the day

    • Quiz on APLA